Karachi is the largest city of Pakistan. The temperature change in Karachi is studied in this research by analyzing the time series data of mean maximum temperature (MMxT), mean minimum temperature (MMiT) and mean annual temperature (MAT) from 1947 to 2005 (59 years). Data is analyzed in three parts by running linear regression and by taking anomalies of all time periods: (a) whole period from 1947–2005; (b) phase one 1947–1975 and (c) phase two 1976–2005. During 1947 to 2005 MMxT has increased about 4.6°C, MMiT has no change and MAT has increased 2.25°C. During 1947–1975, MMxT increased 1.9°C, in this period there is − 1.3°C decrease in MMiT and MAT has raised upto 0.3°C. During 1976–2005, the MMxT, MMiT and MAT increased 2.7°C, 1.2°C and 1.95°C, respectively. The analysis shows significantly the role of extreme vulnerability of MMxT in rising the temperature of Karachi than the MMiT.